Therapeutic Enhancement of Protective Immunity during Experimental Leishmaniasis
نویسندگان
چکیده
منابع مشابه
Therapeutic Enhancement of Protective Immunity during Experimental Leishmaniasis
BACKGROUND Leishmaniasis remains a significant cause of morbidity and mortality in the tropics. Available therapies are problematic due to toxicity, treatment duration and emerging drug resistance. Mouse models of leishmaniasis have demonstrated that disease outcome depends critically on the balance between effector and regulatory CD4(+) T cell responses, something mirrored in descriptive studi...
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Experimental leishmaniasis is an excellent model system for analyzing Th1/Th2 differentiation. Resistance to Leishmania (L.) major depends on the development of a L. major specific Th1 response, while Th2 differentiation results in susceptibility. There is growing evidence that the microenvironment of the early affected tissue delivers the initial triggers for Th-cell differentiation. To analyz...
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Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease. This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity, particularly those associated with s...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2011
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001316